Population
Tissue extracts from platelets, brain, heart, intestine, liver, and lung
Design
Preclinical
Authors
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May indicate cGMP-independent NO signaling in animals; leaves open relevance to human cardiovascular therapies.
Demonstrates a novel mechanism of action for nitric oxide-generating agents via activation of an endogenous ADP-ribosyltransferase, independent of the classical cGMP pathway.
Brüne et al. (1989) studied this question.
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