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June 3, 2016OncotargetOpen Access

Increased serum levels of betatrophin in pancreatic cancer-associated diabetes

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Population

105 Taiwanese subjects including 15 healthy subjects, 12 patients with pancreatic ductal adenocarcinoma and…

Design

Cross-sectional

Authors

HSHendra SusantoTLTa-Yu LiuCCChang-Chiang Chen

Discussion

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Overview

May aid PDAC-DM detection in cross-sectional data; hypothesis-generating and requires prospective validation before clinical adoption.

Structured PICO

P
Population
105 Taiwanese subjects including 15 healthy subjects, 12 patients with pancreatic ductal adenocarcinoma and normal glucose tolerance (PDAC-NGT), 12 with PDAC and impaired glucose tolerance (PDAC-IGT), and 66 with PDAC and diabetes mellitus (PDAC-DM).
C
Comparator
Healthy subjects
O
Outcome
Serum betatrophin and CA19-9 levels, and their diagnostic performance (AUC) for PDAC-associated diabetessurrogate

Betatrophin combined with CA19-9 may serve as a highly accurate potential biomarker for pancreatic cancer-associated diabetes.

Cite This Study

Susanto et al. (2016) studied this question.

synapsesocial.com/papers/6a893994b4e829b19bd438d7https://doi.org/10.18632/oncotarget.9815
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Circulating betatrophin is elevated in patients with type 1 and type 2 diabetes2015 · 100 citations
  2. 2Circulating Betatrophin Levels Are Increased in Anorexia and Decreased in Morbidly Obese Women2015 · 54 citations
  3. 3Elevated circulating lipasin/betatrophin in human type 2 diabetes and obesity2014 · 242 citations
  4. 4A dual role of lipasin (betatrophin) in lipid metabolism and glucose homeostasis: consensus and controversy2014 · 113 citations
  5. 5Pancreatectomy Predicts Improved Survival for Pancreatic Adenocarcinoma2014 · 45 citations