Population
Cultured pulmonary artery endothelial (CPAE) cells
Comparison
Dexamethasone (1 microM to 10 nM) for 16-72 hours vs Untreated cells (implied)
Design
Preclinical
Follow-up
16-72 hours
Authors
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May increase pulmonary endothelial ANP clearance; leaves open in vivo effects on natriuresis or fluid balance during glucocorticoid use.
Glucocorticoids upregulate ANP-R2 clearance receptors on pulmonary artery endothelial cells, providing direct evidence for steroid hormone regulation of ANP receptors.
Lanier-Smith et al. (1991) studied this question.
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