Why the study?
Does endothelin induce vasodilation via endothelium-derived relaxing factors and prostanoids in rat hindquarters?
Population
Anesthetized rats and isolated buffer-perfused hindquarters of pithed rats
Comparison
Endothelin-1 and Endothelin-3 vs Acetylcholine, baseline conditions, and…
Design
Preclinical
Authors
Loading...
ET-1 vasodilation in rat hindquarters is independent of EDRF and prostanoids; hypothesis-generating for alternative mechanisms and does not inform clinical practice.
Does endothelin induce vasodilation via endothelium-derived relaxing factors and prostanoids in rat hindquarters?
Endothelin-induced vasodilation in rat hindquarters does not appear to be mediated by endothelium-derived relaxing factors or prostanoids.
Ohlstein et al. (1990) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: