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January 1, 1998Journal of Cardiovascular Pharmacology

Hemodynamic Effects of a Selective Endothelin-A Receptor Antagonist in Deoxycorticosterone Acetate-Salt Hypertensive Rats

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Why the study?

Does BMS-182874 alter blood pressure, cardiac output, and total peripheral conductance in DOCA-salt hypertensive rats?

Population

Conscious, unrestrained DOCA-salt hypertensive rats and Sham-operated control rats (SHAM)

Comparison

Bolus i.v. infusion of BMS-182874 vs Vehicle-treated controls

Design

Preclinical

Authors

MYMing YuCape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South AfricaVGVenkat GopalakrishnanUniversity of SaskatchewanJMJ. Robert McNeillUniversity of British Columbia Hospital

Discussion

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Implication

ETA antagonism may lower BP via conductance in salt-sensitive models; leaves open human translation.

Structured PICO

Does BMS-182874 alter blood pressure, cardiac output, and total peripheral conductance in DOCA-salt hypertensive rats?

P
Population
Conscious, unrestrained DOCA-salt hypertensive rats and Sham-operated control rats (SHAM)
I
Intervention
Bolus i.v. infusion of BMS-182874 (selective ETA receptor antagonist)
C
Comparator
Vehicle-treated controls
O
Outcome
Time-course changes in blood pressure (BP), cardiac output (CO), and total peripheral conductance (TPC)surrogate

In DOCA-salt hypertensive rats, ETA receptor antagonism lowers blood pressure primarily by increasing total peripheral conductance rather than altering cardiac output.

Cite This Study

Yu et al. (1998) studied this question.

synapsesocial.com/papers/6a893fb04e16d35695eb1826https://doi.org/10.1097/00005344-199800001-00074

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Discrimination between ETA‐ and ETB‐receptor‐mediated effects of endothelin‐1 and [Ala1,3,11,15]endothelin‐1 by BQ‐123 in the anaesthetized rat1992 · 93 citations
  2. 2Telemetric Monitoring of Cardiovascular Parameters in Conscious Spontaneously Hypertensive Rats1993 · 99 citations
  3. 3The Discovery of Sulfonamide Endothelin Antagonists and the Development of the Orally Active ETA Antagonist 5-(Dimethylamino)-N-(3,4-dimethyl-5- isoxazolyl)-1-naphthalenesulfonamide1994 · 137 citations
  4. 4Effects of WAY-123,398, a New Class III Antiarrhythmic Agent, on Cardiac Refractoriness and Ventricular Fibrillation Threshold in Anesthetized Dogs: A Comparison with UK-68798, E-4031, and dl-Sotalol1992 · 62 citations
  5. 5Antihypertensive Effects of a Novel Endothelin-A Receptor Antagonist in Rats1995 · 54 citations