Population
Aortic rings and perfused mesenteric vascular beds from adult male rats of Sprague-Dawley, Wistar-Kyoto, and…
Comparison
Tempol vs Control (absence of tempol)
Design
Preclinical
Authors
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Highlights superoxide's role in Ang II vasoconstriction in hypertensive models; leaves open translation of Tempol to human hypertension therapy.
Tempol selectively attenuates Ang II-evoked vasoconstriction in an endothelium-dependent manner, suggesting superoxide anions mediate this response by quenching nitric oxide, particularly in spontaneously hypertensive rats.
Shastri et al. (2002) studied this question.
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