This case report provides evidence of coxsackievirus aggregates in the muscle cells of a patient with polymyositis, suggesting a potential viral etiology.
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Does not warrant changes in polymyositis management; leaves open viral etiology for further study.
Muscle biopsy specimens of a patient with polymyositis showed crystalline structures resembling picornavirus aggregates within muscle cells. The patient's serum reacted in an indirect immunofluorescence assay with autologous muscle cells. A strongly positive immunofluorescence staining was also noted when a section of muscle tissue was reacted with coxsackievirus A9 antiserum, and a weakly positive reaction was noted with coxsackievirus B2 antiserum. No staining was observed after treatment with antiserum to poliovirus type 1 or echovirus types 11 and 22.
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Györkey et al. (1978) studied this question.
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