Why the study?
Does oral propafenone increase pacing threshold in patients chronically paced for sick sinus syndrome or AV block?
Population
36 patients chronically paced for sick sinus syndrome or AV block with unipolar pacemakers with noninvasive…
Comparison
Oral propafenone 450 mg/day initially, increased… vs Baseline (pre-treatment)
Design
Cohort
Follow-up
7 days per dosage
Authors
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Propafenone associated with higher atrial/ventricular thresholds; leaves open whether monitoring or dose adjustment improves outcomes in paced patients.
Does oral propafenone increase pacing threshold in patients chronically paced for sick sinus syndrome or AV block?
Oral propafenone therapy causes a dose-dependent increase in atrial and ventricular pacing thresholds that is proportional to QRS widening, warranting caution in patients with high baseline thresholds.
Bianconi et al. (1992) studied this question.
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