January 1, 2002Endocrinology

Central Nervous System-Specific Glycosylation of the Type A Natriuretic Peptide Receptor

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Population

Rat and bovine tissues (peripheral and central nervous system)

Design

Preclinical

Authors

DMDieter MüllerNew South Wales Department of Health RMRalf MiddendorffJustus-Liebig-Universität Gießen JOJames OlceseFlorida State University

Discussion

Member takes

Implication

Tissue-specific GC-A glycosylation patterns warrant targeted CNS studies; leaves open functional or therapeutic relevance in cardiovascular models.

Structured PICO

Population

Rat and bovine tissues (peripheral and central nervous system)

Intervention

UV light-induced affinity cross-linking to (125)I-ANP and N-glycosidase F treatment

Outcome

Size heterogeneity and glycosylation of the type A natriuretic peptide receptor (GC-A)surrogate

The type A natriuretic peptide receptor undergoes tissue-specific differential N-linked glycosylation in the central nervous system compared to peripheral tissues, which does not alter its binding affinity or signaling activity.

Cite This Study

Müller et al. (2002) studied this question.

synapsesocial.com/papers/6a894296abe412682d92d41e https://doi.org/10.1210/endo.143.1.8597

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Implication

Tissue-specific GC-A glycosylation patterns warrant targeted CNS studies; leaves open functional or therapeutic relevance in cardiovascular models.

Central Nervous System-Specific Glycosylation of the Type A Natriuretic Peptide Receptor

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Central Nervous System-Specific Glycosylation of the Type A Natriuretic Peptide Receptor

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider