What question did this study set out to answer?

To evaluate how altering the end-diastolic trans-septal pressure gradient impacts the radius of septal curvature, regional left ventricular geometry, and wall thickening dynamics.

September 1, 1984Investigative Radiology

The Effect of Pulmonic and Aortic Constriction on Regional Left Ventricular Thickening Dynamics, Geometry and the Radius of Septal Curvature

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Authors

RSRobert A. SlutskyUniversity of San Diego WPWallace W. PeckHoag Memorial Hospital Presbyterian GMG.B.John ManciniUniversity of British Columbia

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Implication

Trans-septal gradient changes predictably alter septal curvature and thickening in dogs; leaves open relevance to human ventricular geometry or gated CT use.

Key Points

To evaluate how altering the end-diastolic trans-septal pressure gradient impacts the radius of septal curvature, regional left ventricular geometry, and wall thickening dynamics.
Obtained cross-sectional cardiac dynamics using prospectively gated computed transmission tomography (CT) in 6 dogs (N=6).
Evaluated hemodynamics across a control state, two levels of pulmonary artery constriction (PA1 and PA2), and acute aortic constriction (Ao).
Measured simultaneous right and left ventricular pressures using fluid-filled polyethylene catheters alongside CT imaging.
The end-diastolic radius of septal curvature ratio increased as delta [LVEDP-RVEDP] decreased, shifting from 1.03 ± 0.13 at control to 1.20 ± 0.18 at PA1, 1.27 ± 0.14 at PA2, and 0.87 ± 0.11 at Ao.
Declining trans-septal pressure gradients led to a significant reduction in septal wall thickening (P < 0.005), while anterior and lateral wall thickening showed significantly less change.
Pulmonary artery hypertension significantly decreased left ventricular end-diastolic volume and percent delta volume (P < 0.005), while reducing septum-free wall distance and percent shortening along that dimension (P < 0.01).

Cite This Study

Slutsky et al. (1984) studied this question.

synapsesocial.com/papers/6a8945866fc170cbc2fb92f1 https://doi.org/10.1097/00004424-198409000-00008

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Implication

Trans-septal gradient changes predictably alter septal curvature and thickening in dogs; leaves open relevance to human ventricular geometry or gated CT use.

The Effect of Pulmonic and Aortic Constriction on Regional Left Ventricular Thickening Dynamics, Geometry and the Radius of Septal Curvature

Discussion

Member takes

Implication

Key Points

Cite This Study

The Effect of Pulmonic and Aortic Constriction on Regional Left Ventricular Thickening Dynamics, Geometry and the Radius of Septal Curvature

Discussion

Member takes

Implication

Key Points

Cite This Study

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