What question did this study set out to answer?

To determine whether rapid alterations in plasma MM-creatine kinase isoform profiles can reliably and promptly detect myocardial reperfusion following coronary occlusion.

September 1, 1986CirculationOpen Access

Early detection of myocardial reperfusion by assay of plasma MM-creatine kinase isoforms in dogs.

View Full Paper

Ask AI

Bookmark

Why the study?

Does the rate of increase in plasma MMA% allow for the early detection of myocardial reperfusion in dogs with coronary occlusion?

Population

30 conscious dogs with induced coronary occlusion

Comparison

Myocardial reperfusion initiated after 1, 2, 3… vs Nonreperfused control dogs

Design

Preclinical

Follow-up

24 hours

Authors

SDS DevriesKathmandu University SBSobel BeWashington University in St. Louis DADana R. AbendscheinPulse Biosciences (United States)

Discussion

Member takes

Implication

Faster MMA% rise may signal reperfusion in canine models; leaves open translation to human reperfusion detection.

Key Points

To determine whether rapid alterations in plasma MM-creatine kinase isoform profiles can reliably and promptly detect myocardial reperfusion following coronary occlusion.
Induced coronary occlusion in 30 conscious dogs, initiating reperfusion after 1, 2, 3, or 4 hours in 21 dogs alongside nonreperfused controls.
Quantified the myocardial MM-creatine kinase isoform (MMA) in serial plasma samples using chromatofocusing and assessed infarct size histochemically at 24 hours.
Plasma MMA percentage increased from a baseline of 13 ± 7% to a peak of 52 ± 13% within 30 to 60 minutes after the onset of reperfusion (n=21).
The rate of MMA% increase was significantly elevated with reperfusion at 1 hour (1.44 ± 0.42%/min), 2 hours (1.28 ± 0.45%/min), and 3 hours (1.02 ± 0.27%/min) compared to nonreperfused controls (0.29 ± 0.09%/min; p < 0.001), but not at 4 hours (0.48 ± 0.34%/min).
The rate of increase in MMA% showed no correlation with peak total creatine kinase activity (r = -0.1) or histochemical infarct size (r = -0.003).

Structured PICO

Does the rate of increase in plasma MMA% allow for the early detection of myocardial reperfusion in dogs with coronary occlusion?

Population

30 conscious dogs with induced coronary occlusion

Intervention

Myocardial reperfusion initiated after 1, 2, 3, or 4 hours (n=21)

Comparator

Nonreperfused control dogs

Outcome

Rate of increase in plasma MMA% (myocardial isoform of MM-creatine kinase)surrogate

Characterization of the rate of increase in plasma MMA% permits prompt, reliable, and noninvasive detection of early myocardial reperfusion.

Cite This Study

Devries et al. (1986) studied this question.

synapsesocial.com/papers/6a8948c181d3bfa98ef7c1cd https://doi.org/10.1161/01.cir.74.3.567

View Full Paper

Ask AI

Bookmark

Early detection of myocardial reperfusion by assay of plasma MM-creatine kinase isoforms in dogs.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Early detection of myocardial reperfusion by assay of plasma MM-creatine kinase isoforms in dogs.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider