July 1, 1986Circulation
Diagnostic changes in plasma creatine kinase isoforms early after the onset of acute myocardial infarction.
Why the study?
Does the ratio of plasma MMA to MMC creatine kinase isoforms allow for early diagnosis of acute myocardial infarction compared to controls?
Population
61 subjects, comprising 28 patients with acute myocardial infarction, 7 control patients with coronary…
Comparison
Analysis of relative activities of MM creatine… vs Normal control subjects and control patients…
Design
Cross-sectional
Authors
Discussion
Loading...
Member takes
Implication
Elevated MMA/MMC ratio may support early MI detection; leaves open prospective validation before clinical adoption.
Structured PICO
Does the ratio of plasma MMA to MMC creatine kinase isoforms allow for early diagnosis of acute myocardial infarction compared to controls?
P
Population
61 subjects, comprising 28 patients with acute myocardial infarction, 7 control patients with coronary artery disease (angina), and 26 normal control subjects.
I
Intervention
Analysis of relative activities of MM creatine kinase (CK) isoforms in plasma, specifically the ratio of MMA to MMC.
C
Comparator
Normal control subjects and control patients with coronary artery disease (angina).
O
Outcome
Ratio of MMA to MMC in the first available plasma sample.surrogate
The ratio of MMA to MMC isoforms of creatine kinase is significantly elevated within hours of acute myocardial infarction onset, offering a potential early diagnostic marker.
Cite This Study
Jaffe et al. (1986) studied this question.