Population
Cardiac and skeletal muscle sarcoplasmic reticulum (SR) preparations
Comparison
Synthetic 45 amino acid peptide corresponding to… vs Absence of peptide A45, and comparison between…
Design
Preclinical
Authors
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Peptide A45 may relieve phospholamban inhibition of cardiac SERCA in vitro; leaves open therapeutic translation from animal SR preparations.
Peptide A45 competes with the ATPase for phospholamban or peptide C28W, removing inhibition of the pump and demonstrating functional analogy between these inhibitors.
Vorherr et al. (1992) studied this question.
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