Why the study?
Does heparin affect fibrinolysis of preformed fibrin in vitro?
Population
In vitro models using human urokinase, human fibrinolytic euglobulins, human pyrogen plasma, bovine fibrin…
Comparison
Heparin (high and small concentrations) vs Absence of plasma, serum, or albumin fraction
Design
Preclinical
Authors
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No practice change from this Level 5 model; leaves open clinical translation of concentration-dependent effects.
Does heparin affect fibrinolysis of preformed fibrin in vitro?
Heparin's effect on fibrinolysis is concentration-dependent and requires the presence of albumin.
Kaulla et al. (1958) studied this question.
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