Key result
Heparin inhibited various fibrinolytic activators at high concentrations (10-1000 units/ml) and at lower concentrations (0.5-2.5 units/ml) in the presence of plasma, but had no effect on plasmin.
Why the study?
Does heparin inhibit fibrinolytic activators and plasmin activity in vitro?
Population
In vitro models using various fibrinolytic activators and human plasma.
Design
Preclinical
Authors
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May indicate antifibrinolytic activity of heparin in vitro; leaves open relevance to clinical bleeding or thrombosis risk.
Does heparin inhibit fibrinolytic activators and plasmin activity in vitro?
Heparin exhibits an antifibrinolytic effect by inhibiting various fibrinolytic activators, though it does not directly affect plasmin activity.
Nilsson et al. (1964) studied this question. Heparin was evaluated on Inhibition of fibrinolytic activators and plasmin activity. Heparin inhibited various fibrinolytic activators at high concentrations (10-1000 units/ml) and at lower concentrations (0.5-2.5 units/ml) in the presence of plasma, but had no effect on plasmin.
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