March 31, 2011PLoS ONEOpen Access

Novel Pathway of Adipogenesis through Cross-Talk between Adipose Tissue Macrophages, Adipose Stem Cells and Adipocytes: Evidence of Cell Plasticity

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Population

Human adipocytes and the stromal vascular fraction containing adipose tissue macrophages and adipose stem…

Comparison

Co-culture of adipocytes with ATMs and ASCs for… vs Before co-culture

Design

Preclinical

Follow-up

24 hours

Authors

GCGregorio D. ChazenbalkUniversity of California, Los Angeles SHSaleh HeneidiCedars-Sinai Medical Center MJMedet JumabayNihon University

Discussion

Member takes

Implication

Supports ATM-to-preadipocyte differentiation in vitro; hypothesis-generating and leaves open in vivo relevance.

Structured PICO

Population

Human adipocytes and the stromal vascular fraction containing adipose tissue macrophages (ATMs) and adipose stem cells (ASCs) isolated from human adipose tissue

Intervention

Co-culture of adipocytes with ATMs and ASCs for 24 hours

Comparator

Before co-culture

Outcome

Formation of new preadipocytes, lipid accumulation, and C/EBPα and PPARγ gene expressionsurrogate

Cross-talk between adipocytes, ATMs, and ASCs promotes preadipocyte formation, suggesting a novel adipogenic pathway involving differentiation of ATMs to preadipocytes.

Cite This Study

Chazenbalk et al. (2011) studied this question.

synapsesocial.com/papers/6a894b4ca90c2f4c44fb8ff8 https://doi.org/10.1371/journal.pone.0017834

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Novel Pathway of Adipogenesis through Cross-Talk between Adipose Tissue Macrophages, Adipose Stem Cells and Adipocytes: Evidence of Cell Plasticity

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Novel Pathway of Adipogenesis through Cross-Talk between Adipose Tissue Macrophages, Adipose Stem Cells and Adipocytes: Evidence of Cell Plasticity

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider