The changing epidemiology of Ebstein’s anomaly and its relationship with maternal mental health conditions: a European registry-based study

264 cases of Ebstein's anomaly among 5.6 million births (including live births, fetal deaths from 20 weeks gestation, and terminations of pregnancy for fetal anomaly) from 15 European Surveillance of Congenital Anomalies Registries in 12 European countries (1982-2011).

Exposure to maternal illnesses and medications in the first trimester of pregnancy (including maternal mental health conditions, beta-thalassemia, and haemorrhage).

Cardiac and non-cardiac malformed controls, excluding cases with genetic syndromes.

Total prevalence per 10,000 births and odds ratios for exposure to maternal illnesses/medications in the first trimester.