What question did this study set out to answer?

Determine the frequency of metastasis in cutaneous squamous cell carcinoma and identify tumor characteristics linked to systemic spread.

December 1, 1965Archives of Dermatology

How Often Does Squamous Cell Carcinoma of the Skin Metastasize?

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Determine the frequency of metastasis in cutaneous squamous cell carcinoma and identify tumor characteristics linked to systemic spread.
Analyzed metastatic tendencies of cutaneous squamous cell carcinoma arising from solar damage versus other predisposing lesions.
Evaluated histological and clinical features associated with high-risk lesions, including tumor size, differentiation grade, cellularity, and invasive pattern.
Metastasis from common squamous cell carcinoma developing on sun-damaged skin is rare, with the vast majority remaining strictly locally aggressive.
Tumors arising from non-solar etiologies—including burns, scars, chronic ulcers, arsenical dermatosis, and radiation injury—exhibit a higher propensity to metastasize.
Tumors marked by large size, high cellularity, diffuse invasion, and anaplastic histology spread more readily and extensively than well-differentiated tumors.

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Implication

Clinical review finds rare metastasis in sun-induced cutaneous squamous cell carcinoma, highlighting higher risks from scars, chronic ulcers, and anaplastic tumors.

Cite This Study

Herbert Z. Lund (1965) studied this question.

synapsesocial.com/papers/6a894cf141f4089922bd5248 https://doi.org/10.1001/archderm.1965.01600180027004

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Implication

Clinical review finds rare metastasis in sun-induced cutaneous squamous cell carcinoma, highlighting higher risks from scars, chronic ulcers, and anaplastic tumors.

How Often Does Squamous Cell Carcinoma of the Skin Metastasize?

Key Points

Discussion

Implication

Cite This Study

How Often Does Squamous Cell Carcinoma of the Skin Metastasize?

Key Points

Discussion

Implication

Cite This Study

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