January 1, 1989AJP Heart and Circulatory Physiology

Electrical and mechanical responses of rat saphenous vein to short-term pressure load

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Population

Rat distal saphenous vein (in situ and in vitro models)

Comparison

Short-term pressure load vs Control pressure (2.2 +/- 0.2 mmHg)

Design

Preclinical

Follow-up

1 hour

Authors

EME. MonosSemmelweis University SCS. J. ContneyMedical College of Wisconsin ACAllen W. CowleyPreventive Cardiology

Discussion

Member takes

Implication

Supports venous autoregulation via pressure-induced depolarization in animals; leaves open translation to human physiology and clinical relevance.

Structured PICO

Population

Rat distal saphenous vein (in situ and in vitro models)

Intervention

Short-term pressure load (elevation of intraluminal pressure up to 15 mmHg or via femoral artery to saphenous vein shunt)

Comparator

Control pressure (2.2 +/- 0.2 mmHg)

Outcome

Smooth muscle membrane potential (Em) depolarization, active isometric stress, and isobaric strainsurrogate

Short-term pressure load causes sustained, reversible venous smooth muscle cell depolarization and active stress generation, supporting intrinsic capacity autoregulation in peripheral veins.

Cite This Study

Monos et al. (1989) studied this question.

synapsesocial.com/papers/6a894d47a4df84145ecaff6e https://doi.org/10.1152/ajpheart.1989.256.1.h47

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Implication

Supports venous autoregulation via pressure-induced depolarization in animals; leaves open translation to human physiology and clinical relevance.

Electrical and mechanical responses of rat saphenous vein to short-term pressure load

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Electrical and mechanical responses of rat saphenous vein to short-term pressure load

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider