Why the study?
Does a 2-week 45 degrees head-up tilt alter the mechanical and electrical properties of the saphenous vein in adult male Sprague-Dawley rats?
Population
Adult male Sprague-Dawley rats
Comparison
2-week 45 degrees head-up tilt period in… vs Nontilted controls
Design
Preclinical
Follow-up
2 weeks
Authors
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Findings from this rat model do not support clinical translation; leaves open whether venous hyperpolarization occurs in human orthostasis.
Does a 2-week 45 degrees head-up tilt alter the mechanical and electrical properties of the saphenous vein in adult male Sprague-Dawley rats?
Chronic moderate elevation of venous intraluminal pressure via head-up tilt induces hyperpolarization of vascular smooth muscle and increases venous capacity in rats.
Monos et al. (1989) studied this question.
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