January 1, 2003Physiological ResearchOpen Access

Remodeling of the rat saphenous vein network in response to long-term gravitational load.

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Why the study?

Does chronic gravitational load induce network changes in the saphenous vein superficial tributary system in rats?

Population

28 male Sprague-Dawley rats

Comparison

Tilted tube cages for two weeks to induce… vs Normal cages and horizontally positioned tube…

Design

Preclinical

Follow-up

2 weeks

Authors

MLMiklós LórántSemmelweis University GNGL NádasySemmelweis University GRGábor RaffaiSemmelweis University

Discussion

Member takes

Implication

Supports gravitational venous remodeling in rat models; leaves open any human translation or clinical relevance.

Structured PICO

Does chronic gravitational load induce network changes in the saphenous vein superficial tributary system in rats?

Population

28 male Sprague-Dawley rats

Intervention

Tilted tube cages (45-degree head-up position) for two weeks to induce chronic gravitational load

Comparator

Normal cages (n=10) and horizontally positioned tube cages (n=4)

Outcome

Network changes in the saphenous vein superficial tributary system (branching angles, lengths of venous segments, and diameters)surrogate

Chronic gravitational load induces adaptive remodeling of the saphenous vein network in rats, characterized by increased diameters and reduced branching angles.

Cite This Study

Lóránt et al. (2003) studied this question.

synapsesocial.com/papers/6a8d1cbde4447a32cadcd279 https://doi.org/10.33549/physiolres.930346

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