Why the study?
The study was conducted to identify the pathogenesis of cardiovascular illnesses in obese patients, given an unclear relationship between metabolically unhealthy individuals and increased CAD risk.
Does obesity and adipose tissue-mediated inflammation increase the risk of coronary artery disease in metabolically healthy and unhealthy obese adults?
Population
Eight publications evaluating metabolically healthy and unhealthy obese adults
Comparison
Metabolically healthy obese people vs unhealthy obese adults
Design
Systematic review of seven observational studies and one narrative review
Authors
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Highlights novel pathogenic links in obese CV patients; leaves open targeted interventions pending prospective validation.
Does obesity and adipose tissue-mediated inflammation increase the risk of coronary artery disease in metabolically healthy and unhealthy obese adults?
This systematic review highlights that both metabolically healthy and unhealthy obese individuals are at increased risk for coronary artery disease, driven significantly by adipose tissue-mediated inflammation.
Manoharan et al. (2022) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: