April 29, 2009Arthritis & Rheumatism

Transmembrane BAFF from rheumatoid synoviocytes requires interleukin‐6 to induce the expression of recombination‐activating gene in B lymphocytes

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Structured PICO

Population

B cells from healthy control subjects cocultured with fibroblast-like synoviocytes (FLS) from patients with rheumatoid arthritis (RA) and osteoarthritis (OA)

Intervention

Coculture with RA FLS; use of blocking antibodies, short hairpin RNA, and recombinant cytokine (IL-6)

Comparator

Coculture with OA FLS

Outcome

Re-expression of RAG messenger RNA (mRNA) and proteins, and activity of RAG enzymessurrogate

Transmembrane BAFF and IL-6 from rheumatoid synoviocytes provide two independent signals required for RAG gene re-expression in B cells.

Discussion

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Implication

May implicate RA synoviocyte BAFF/IL-6 in B-cell RAG re-expression; hypothesis-generating for pathogenesis, requires human validation.

Cite This Study

Rochas et al. (2009) studied this question.

synapsesocial.com/papers/6a894fa3176d2ac34cfb93dc https://doi.org/10.1002/art.24498

View Full Paper

Ask AI

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Transmembrane BAFF from rheumatoid synoviocytes requires interleukin‐6 to induce the expression of recombination‐activating gene in B lymphocytes

Structured PICO

Discussion

Implication

Cite This Study

Transmembrane BAFF from rheumatoid synoviocytes requires interleukin‐6 to induce the expression of recombination‐activating gene in B lymphocytes

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider