Why the study?
Does total heart replacement using dual intracorporeal continuous-flow pumps maintain normal hemodynamics and end-organ function in a chronic bovine model?
Population
6-month-old Corriente crossbred calf (chronic bovine model), n=1
Design
Preclinical
Authors
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Caution against clinical use of dual continuous-flow total artificial hearts; leaves open translation from bovine feasibility to human trials.
Does total heart replacement using dual intracorporeal continuous-flow pumps maintain normal hemodynamics and end-organ function in a chronic bovine model?
Dual continuous-flow pumps can feasibly serve as a total artificial heart in a bovine model, maintaining normal hemodynamics and end-organ function despite complete pulseless flow.
Frazier et al. (2006) studied this question.
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