February 27, 2009AJP Heart and Circulatory Physiology

Frequency response characteristics of whole body autoregulation of blood flow in rats

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Population

Anesthetized rats (n=11)

Comparison

Alpha-adrenergic receptor stimulation… vs Control conditions during computer-regulated…

Design

Preclinical

Authors

HSHarald M. StaussVascular Medicine KRKevin R. RarickChildren's Hospital of Wisconsin RDRichard J. DeklotzMedical College of Wisconsin

Discussion

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Implication

Alpha(1) stimulation may extend autoregulation range in animal models; leaves open relevance to human BP variability.

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Population

Anesthetized rats (n=11)

Intervention

Alpha(1)-adrenergic receptor stimulation (phenylephrine, 1 mg.ml(-1).h(-1) iv) during computer-regulated cardiac pacing-induced blood pressure variability

Comparator

Control conditions (NaCl, 1 ml/h iv) during computer-regulated cardiac pacing-induced blood pressure variability

Outcome

Frequency response characteristics of whole body autoregulation of blood flow (transfer function analyses between mean arterial pressure and cardiac output, and between mean arterial pressure and total vascular conductance)surrogate

Whole body autoregulation of blood flow operates most effectively at frequencies below 0.05 Hz, which overlaps with the lower end of the frequency band of very low-frequency blood pressure variability in rats.

Cite This Study

Stauss et al. (2009) studied this question.

synapsesocial.com/papers/6a895e658af63dd37bc10f3b https://doi.org/10.1152/ajpheart.01262.2008

View Full Paper

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Frequency response characteristics of whole body autoregulation of blood flow in rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Frequency response characteristics of whole body autoregulation of blood flow in rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider