Experimental study demonstrates photoinduced copper-catalyzed carbonylation of alkyl iodides at room temperature, indicating a mild, cost-effective route to amides and related derivatives.
A general photoinduced copper-catalyzed carbonylative cross-coupling of alkyl iodides with amines for the synthesis of amides under mild conditions has been reported. Using a readily accessible, inexpensive copper complex, [Cu(bcp)DPEphos]PF6, the reaction proceeds at room temperature and accommodates a broad range of amines. Notably, the transformation can also be performed under ambient carbon monoxide pressure and can be extended to hydrazines, alcohols, and sodium hydroxide.
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Adaoudi et al. (2026) studied this question.
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