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August 22, 2026AnimalsOpen Access

Effects of Replacing Dietary Fishmeal with Enzyme-Treated Soybean Protein on Growth Performance, Serum Biochemical Indices, Antioxidant, Digestive Enzyme Activities, Intestinal Barrier Integrity and Relative mRNA Expression Levels of Juvenile Largemouth Bass (Micropterus salmoides)

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Authors

DXDong XiaJGJie GuoHXHongsen Xu

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Overview

Controlled feeding trial demonstrates that 25% enzyme-treated soybean protein replacement improves growth and gut health in largemouth bass, suggesting a viable alternative to fishmeal.

Key Points

  • To evaluate the effects of replacing dietary fishmeal with enzyme-treated soybean protein on growth performance, antioxidant capacity, and intestinal health in juvenile largemouth bass.
  • Conducted an 8-week feeding trial using 450 juvenile largemouth bass (initial weight 15.52 ± 0.04 g) randomly allocated into five dietary groups with 0%, 12.5%, 25.0%, 37.5%, and 50.0% fishmeal replacement by enzyme-treated soybean protein (ETSP).
  • Evaluated growth metrics, serum biochemical markers, antioxidant enzyme activities, gut histology, serum permeability markers (DAO, D-Lac, LPS), and relative intestinal mRNA expression.
  • The 25.0% ETSP group achieved the highest final body weight, weight gain, and specific growth rate, as well as the lowest feed conversion ratio.
  • ETSP inclusion significantly elevated antioxidant enzyme activities (T-SOD, CAT, GSH-Px) and lowered malondialdehyde levels (p < 0.05), alongside reduced serum AST, DAO, D-lactate, and lipopolysaccharide levels.
  • The 25.0% replacement level upregulated tight junction genes (occludin, claudins, ZO-1, ZO-2), peptide/amino acid transporters (LAT1, PEPT1, PEPT2), and anti-inflammatory IL-10, while downregulating pro-inflammatory IL-8 and TNF-α.

Cite This Study

Xia et al. (2026) studied this question.

synapsesocial.com/papers/6a895eaeca7ade938187cc94https://doi.org/10.3390/ani16162589
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Performance and Health Status of Juvenile Largemouth Bass ( <i>Micropterus nigricans</i> ) Fed Inclusions of Enzyme‐Treated and Low‐Oligosaccharide Soy Proteins2026
  2. 2Effects of partial substitution of enzymatic hydrolysate of poultry by-product meal for fishmeal on the growth performance, hepatic health, antioxidant capacity, and immunity of juvenile largemouth bass (Micropterus salmoides)2024 · 8 citations
  3. 3Effects of Replacing Fishmeal with Enzymatically Hydrolyzed Pork Bone Meal (EHPBM) on Growth, Antioxidant Capacity, and Nutritional Metabolism in Micropterus salmoides2025
  4. 4Excessive Replacement of Fish Meal by Soy Protein Concentrate Resulted in Inhibition of Growth, Nutrient Metabolism, Antioxidant Capacity, Immune Capacity, and Intestinal Development in Juvenile Largemouth Bass (Micropterus salmoides)2024 · 20 citations
  5. 5Mixed plant protein sources balanced with crystalline amino acids as a substitute for fish meal: Effects on growth, health and gut microbiota of juvenile largemouth bass (Micropterus salmoides)2026 · 1 citations