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The transcription factor NF-ĸB regulates expression of many genes that are involved in inflammation, infection and tumor growth, and may play an important role in cardiovascular disease. Agents that inhibit this pathway, such as nonsteroidal antiinflammatory drugs and glucocorticoids, can reduce the inflammatory response, but their role in the treatment of cardiovascular disease is poorly understood. In this review, we describe various kinds of NF-ĸB inhibitors and discuss their potential role in the treatment of cardiovascular disease.
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Hishikawa et al. (2002) studied this question.
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