What does this research mean for the field?

The major C-terminal domain of Staphylococcus aureus staphylocoagulase folds into a single-layer β-sheet similar to the MORN family of tandem repeats, and its folding pathway is contingent upon the presence of its substrate, fibrinogen. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To resolve the 3D structure and substrate-recognition mechanism of the C-terminal region of Staphylococcus aureus staphylocoagulase during fibrinogen cleavage.

August 22, 2026Biological ChemistryOpen Access

Structural basis for the procoagulant activity of Staphylococcus aureus staphylocoagulase

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Authors

PFPablo Fuentes‐PriorInstitut Botànic de Barcelona AMAshoka A. MaddurFujifilm (Japan)PPPeter PanizziAuburn University

Discussion

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Implication

Structural modeling uncovers substrate-dependent folding in the staphylocoagulase C-terminal domain, highlighting mechanisms driving fibrin clot formation and biofilm development.

Key Points

To resolve the 3D structure and substrate-recognition mechanism of the C-terminal region of Staphylococcus aureus staphylocoagulase during fibrinogen cleavage.
Generated 3D structural models of the fibrinogen-binding C-terminal domain of staphylocoagulase.
Analyzed the folding pathway of the C-terminal domain in the presence and absence of fibrinogen.
Identified that the major C-terminal domain of staphylocoagulase folds into a single-layer β-sheet homologous to MORN family tandem repeats.
Demonstrated that proper folding of the C-terminal domain is contingent upon direct interaction with its substrate, fibrinogen, facilitating procoagulant complex assembly.

Cite This Study

Fuentes‐Prior et al. (2026) studied this question.

synapsesocial.com/papers/6a895f53ca7ade938187de1e https://doi.org/10.1515/hsz-2025-0253

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Implication

Structural modeling uncovers substrate-dependent folding in the staphylocoagulase C-terminal domain, highlighting mechanisms driving fibrin clot formation and biofilm development.

Structural basis for the procoagulant activity of Staphylococcus aureus staphylocoagulase

Discussion

Member takes

Implication

Key Points

Cite This Study

Structural basis for the procoagulant activity of Staphylococcus aureus staphylocoagulase

Discussion

Member takes

Implication

Key Points

Cite This Study

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