What does this research mean for the field?

Age, comorbidity burden, APACHE II score, mechanical ventilation, and vasopressor use independently predict ICU mortality among patients aged 75 years and older in a resource-limited setting. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To identify admission characteristics and independent predictors of ICU mortality among elderly patients aged 75 years and older in a resource-limited setting.

August 22, 2026Acute and Critical CareOpen Access

Admission characteristics and factors associated with outcomes in elderly patients aged 75 years and older in a level 3 ICU in Nepal: a 4-year registry-based retrospective study

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Authors

KKKishor KhanalIntensive Care Foundation SPSaroj PoudelNepal Development Research Institute SASunidhi AryalGrande International Hospital

Discussion

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Implication

Retrospective observational study reveals key predictors of mortality in elderly intensive care patients, indicating the value of early risk stratification in resource-limited settings.

Key Points

To identify admission characteristics and independent predictors of ICU mortality among elderly patients aged 75 years and older in a resource-limited setting.
Retrospective observational study analyzing N=1,028 patients aged ≥75 years admitted to a level 3 ICU in Nepal over a 4-year period.
Assessed demographics, comorbidities, frailty scores, APACHE II scores, and clinical interventions using univariate, bivariate, and multivariate logistic regression analyses.
The overall ICU mortality rate was 17.5% in a cohort with a mean age of 82±5 years (58.1% male).
Independent predictors of mortality included age (aOR 1.05), comorbidity burden (aOR 1.40), APACHE II score (aOR 1.08), mechanical ventilation (aOR 2.10), and vasopressor use (aOR 1.80).
Frailty, sex, aggressiveness of therapy, and primary system involvement were not independently associated with ICU mortality.

Cite This Study

Khanal et al. (2026) studied this question.

synapsesocial.com/papers/6a895f62ca7ade938187e016 https://doi.org/10.4266/acc.002912

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Implication

Retrospective observational study reveals key predictors of mortality in elderly intensive care patients, indicating the value of early risk stratification in resource-limited settings.

Admission characteristics and factors associated with outcomes in elderly patients aged 75 years and older in a level 3 ICU in Nepal: a 4-year registry-based retrospective study

Discussion

Member takes

Implication

Key Points

Cite This Study

Admission characteristics and factors associated with outcomes in elderly patients aged 75 years and older in a level 3 ICU in Nepal: a 4-year registry-based retrospective study

Discussion

Member takes

Implication

Key Points

Cite This Study

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