What does this research mean for the field?

Adolescents with major depressive disorder who engage in non-suicidal self-injury exhibit increased low-frequency amplitude fluctuations in the left precuneus and increased functional connectivity between the left precuneus and left cuneus, which are significantly associated with NSSI behaviors and motivations. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To investigate the neural mechanisms and functional brain alterations underlying non-suicidal self-injury (NSSI) behaviors and motivations in adolescents with major depressive disorder (MDD).

August 22, 2026PLoS ONEOpen Access

Altered brain function associated with non-suicidal self-injury in adolescents with major depressive disorder: An rs-fMRI study

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Authors

HBHongjuan BaiNingxia Hui Autonomous Region Peoples Hospital SCShaohua ChangNingxia Hui Autonomous Region Peoples Hospital JLJing LiNingxia Hui Autonomous Region Peoples Hospital

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Implication

Neuroimaging study reveals heightened precuneus activity and connectivity in depressed adolescents with non-suicidal self-injury, highlighting potential neural markers for targeted intervention.

Key Points

To investigate the neural mechanisms and functional brain alterations underlying non-suicidal self-injury (NSSI) behaviors and motivations in adolescents with major depressive disorder (MDD).
Recruited 133 adolescent participants, comprising 45 with MDD and NSSI, 46 with MDD without NSSI, and 42 age- and sex-matched healthy controls.
Conducted resting-state functional MRI (rs-fMRI) to evaluate low-frequency amplitude fluctuations (ALFF) and seed-based functional connectivity (FC), assessing associations with NSSI using cross-validation prediction.
Adolescents with MDD engaging in NSSI exhibited increased ALFF in the left precuneus, which significantly associated with NSSI behaviors (cross-validation r = 0.653, p = 0.001).
Increased left precuneus–left cuneus functional connectivity was significantly associated with NSSI behaviors (cross-validation r = 0.601, p = 0.001) and intrapersonal negative reinforcement motivations (cross-validation r = 0.587, p = 0.001).

Cite This Study

Bai et al. (2026) studied this question.

synapsesocial.com/papers/6a895fd3ca7ade938187ec0a https://doi.org/10.1371/journal.pone.0356601

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Implication

Neuroimaging study reveals heightened precuneus activity and connectivity in depressed adolescents with non-suicidal self-injury, highlighting potential neural markers for targeted intervention.

Altered brain function associated with non-suicidal self-injury in adolescents with major depressive disorder: An rs-fMRI study

Discussion

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Implication

Key Points

Cite This Study

Altered brain function associated with non-suicidal self-injury in adolescents with major depressive disorder: An rs-fMRI study

Discussion

Member takes

Implication

Key Points

Cite This Study

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