Genetic Markers of Poliovirus Strains Isolated From Paralytic Patients Prior to and After Sabin Vaccination Programs

J. Furesz; R. E. Armstrong; Patrice Moreau; F. P. Nagler

doi:10.1093/oxfordjournals.aje.a120458

July 1, 1964American Journal of Epidemiology

Genetic Markers of Poliovirus Strains Isolated From Paralytic Patients Prior to and After Sabin Vaccination Programs

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Key Points

Determine the genetic marker profiles of poliovirus strains isolated from patients with paralytic disease before and after the rollout of Sabin oral vaccination programs.
Examined poliovirus isolates recovered from paralytic patients during surveillance periods preceding and following Sabin vaccination initiatives.
Assessed specific genetic and phenotypic markers to characterize circulating viral isolates and differentiate wild-type from attenuated strains.
Identified distinct genetic marker variations between polioviruses isolated before and after widespread administration of the Sabin vaccine.
Delineated differences in marker behavior between circulating wild-type strains and vaccine-related viral isolates in paralytic cases.

Implication

Virological surveillance uncovers genetic marker shifts of poliovirus strains in paralytic cases, highlighting the impact of live oral vaccination programs.

Abstract

J. Furesz, R. E. Armstrong, P. Moreau, F. P. Nagler; Genetic Markers of Poliovirus Strains Isolated From Paralytic Patients Prior to and After Sabin Vaccin

Discussion

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Cite This Study

Furesz et al. (1964) studied this question.

synapsesocial.com/papers/6a8960425edafe343d92d97c https://doi.org/10.1093/oxfordjournals.aje.a120458

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Genetic Markers of Poliovirus Strains Isolated From Paralytic Patients Prior to and After Sabin Vaccination Programs

Key Points

Implication

Abstract

Discussion

Cite This Study

Genetic Markers of Poliovirus Strains Isolated From Paralytic Patients Prior to and After Sabin Vaccination Programs

Key Points

Implication

Abstract

Discussion

Cite This Study

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