ANTIGENIC SEGREGATION OF TYPE 3 POLIOVIRUS ISOLATES RELATED AND UNRELATED TO SABIN'S VACCINE STRAIN WITH THE USE OF MODIFIED WECKER AND McBRIDE TECHNIQUES1

James H. Nakano; Henry M. Gelfand; Jura T. Cole

doi:10.1093/oxfordjournals.aje.a120561

January 1, 1966American Journal of Epidemiology

ANTIGENIC SEGREGATION OF TYPE 3 POLIOVIRUS ISOLATES RELATED AND UNRELATED TO SABIN'S VACCINE STRAIN WITH THE USE OF MODIFIED WECKER AND McBRIDE TECHNIQUES1

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Key Points

Determine whether modified Wecker and McBride serological techniques can effectively differentiate type 3 poliovirus isolates related to Sabin's vaccine strain from unrelated wild strains.
Adapted and applied modified Wecker and McBride serological neutralization assays to characterize type 3 poliovirus isolates.
Evaluated antigenic relationships and neutralization kinetics against the Sabin type 3 oral vaccine reference strain.
Modified serological techniques successfully segregated type 3 poliovirus isolates into vaccine-related and non-vaccine-related antigenic groups.
Antigenic divergence from the parental Sabin strain was clearly distinguishable across isolates without requiring complete genetic sequencing.

Structured PICO

P

Population

Type 3 poliovirus isolates

I

Intervention

Modified Wecker and McBride techniques

O

Outcome

Antigenic segregation

Implication

Laboratory investigation demonstrates antigenic differentiation between Sabin-related and unrelated type 3 poliovirus isolates, highlighting improved methods for viral surveillance.

Abstract

James H. Nakano, Henry M. Gelfand, Jura T. Cole; Antigenic Segregation of Type 3 Poliovirus Isolates Related and Unrelated to Sabin's Vaccine Strain With T

Discussion

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Nakano et al. (1966) studied this question.

synapsesocial.com/papers/6a6f765c78a11c550e092d5f https://doi.org/10.1093/oxfordjournals.aje.a120561

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ANTIGENIC SEGREGATION OF TYPE 3 POLIOVIRUS ISOLATES RELATED AND UNRELATED TO SABIN'S VACCINE STRAIN WITH THE USE OF MODIFIED WECKER AND McBRIDE TECHNIQUES1

Key Points

Structured PICO

Implication

Abstract

Discussion

Cite This Study

ANTIGENIC SEGREGATION OF TYPE 3 POLIOVIRUS ISOLATES RELATED AND UNRELATED TO SABIN'S VACCINE STRAIN WITH THE USE OF MODIFIED WECKER AND McBRIDE TECHNIQUES1

Key Points

Structured PICO

Implication

Abstract

Discussion

Cite This Study

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