Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 1, 2004The Tohoku Journal of Experimental MedicineOpen Access

Effects of Tachycardia on Regional Wall Motion in Acute Ischemic Canine Heart

View Full Paper
Ask AI
Bookmark
Share

Population

8 dogs with occlusion of left anterior descending artery

Comparison

Tachycardia induced by atrial pacing after… vs Inferior vena caval occlusion at a heart rate of…

Design

Preclinical

Authors

YYYoshito YamamotoMiwa HospitalMSMasahito SakumaNihon UniversityHHHidenari HozawaMie Chuo Medical Center

Discussion

Loading...

Member takes

Implication

Hypothesis-generating in acute canine ischemia; human studies required before any clinical relevance.

Structured PICO

P
Population
8 dogs with occlusion of left anterior descending artery
I
Intervention
Tachycardia induced by atrial pacing (heart rates of 90, 120, and 150 beats/minute) after administration of UL-FS49 (a selective bradycardic agent)
C
Comparator
Inferior vena caval occlusion at a heart rate of 90 beats/minute
O
Outcome
Regional wall motion (end-diastolic length, isovolumetric shortening, ejectional shortening) in non-ischemic and ischemic regionssurrogate

In an acute ischemic canine model, tachycardia directly alters regional wall motion dynamics independently of preload reduction.

Cite This Study

Yamamoto et al. (2004) studied this question.

synapsesocial.com/papers/6a89641db4e829b19bd44590https://doi.org/10.1620/tjem.203.111
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mechanisms of augmented segment shortening in nonischemic areas during acute ischemia of the canine left ventricle.1985 · 125 citations
  2. 2Hemodynamic determinants of the time-course of fall in canine left ventricular pressure.1976 · 1,083 citations
  3. 3Alteration of the left ventricular diastolic pressure-segment length relation produced by the pericardium. Effects of cardiac distension and afterload reduction in conscious dogs.1978 · 163 citations
  4. 4The responses of left ventricular end‐systolic pressure‐diameter relationship to acute pressure overload induced by aortic constriction1993 · 4 citations
  5. 5Modification of regional myocardial performance caused by blood withdrawal and infusion in acute ischaemic canine heart1993 · 5 citations