Key result
Intravascular papillary endothelial hyperplasia is a rare lesion (0.03% of biopsies) that most commonly affects females (60%) at a mean age of 46.55 years, typically presenting as an asymptomatic nodule.
Why the study?
Intravascular papillary endothelial hyperplasia is an unusual vascular lesion, and this study aimed to determine its frequency and general features.
Systematic Review (n=125)
Yes
Intravascular papillary endothelial hyperplasia is a rare vascular lesion of the oral mucosa that clinicians should recognize to differentiate from other common lesions like mucoceles and hemangiomas.
Supports inclusion in oral nodule differentials to avoid misdiagnosis; extends epidemiologic profile via systematic review.
BACKGROUND: Intravascular papillary endothelial hyperplasia is an unusual vascular lesion characterized by the proliferation of endothelial cells. The aim of this study was to determine the frequency and general features of this lesion. METHODS: Biopsy records of three oral pathology services were reviewed for intravascular papillary endothelial hyperplasia cases from 1959 to 2020. In addition, a systematic review of case reports and case series was carried out in eight electronic databases. RESULTS: Of the 65 205 retrieved cases, 20 (0.03%) were diagnosed as intravascular papillary endothelial hyperplasia. Mean patient age was 46.55 years, and females (12 cases/60%) were more affected. The lower lip (9 cases/47.36%) was the most commonly affected site, and the lesions were generally asymptomatic (7 cases/63.63%). Clinically, 90% of the lesions presented (18 cases) as a nodule, with a mean size of 1.13 cm. The clinical diagnostic hypotheses most frequently raised were mucocele (6 cases/37.50%) and hemangioma (5 cases/31.25%). An excisional biopsy was chosen in all cases for treatment. Forty-nine studies of the systematic review were included, yielding 105 cases. The literature showed similarity in all variables. CONCLUSION: Despite the uncommon frequency, clinicians and oral pathologists should familiarize themselves with the similarities between intravascular papillary endothelial hyperplasia and some other lesions in terms of clinical and histological features.
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Vieira et al. (2020) conducted a systematic review in Intravascular papillary endothelial hyperplasia in the oral mucosa and jawbones (n=125). Intravascular papillary endothelial hyperplasia was evaluated on Frequency and general features of the lesion. Intravascular papillary endothelial hyperplasia is a rare lesion (0.03% of biopsies) that most commonly affects females (60%) at a mean age of 46.55 years, typically presenting as an asymptomatic nodule.
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