Key result
In human saphenous vein smooth muscle cells, HAS2-mediated hyaluronic acid synthesis is induced by vasodilatory prostaglandins and thrombin, and is critically involved in cell proliferation.
Hyaluronic acid-rich extracellular matrix is maintained after arterialization of vein grafts and may contribute to graft failure via proproliferative functions in venous smooth muscle cells, regulated by COX-2-dependent prostaglandins.
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Hypothesis-generating for HAS2 targeting in vein graft failure; leaves open clinical translation.
Boom et al. (2005) studied Saphenous vein bypass graft failure and atherosclerosis. Vasodilatory prostaglandins, thrombin, and siRNA against HAS2 was evaluated on Hyaluronic acid accumulation, HAS expression, and HA synthesis. In human saphenous vein smooth muscle cells, HAS2-mediated hyaluronic acid synthesis is induced by vasodilatory prostaglandins and thrombin, and is critically involved in cell proliferation.
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