Key result
Atherosclerotic SVGs show decreased total glycosaminoglycans but increased dermatan and chondroitin sulfate versus normal veins.
Why the study?
The glycosaminoglycan composition of normal saphenous veins and atherosclerotic saphenous vein grafts was not well characterized to understand their role in atherosclerosis.
Observational
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Vein graft glycosaminoglycan shifts may signal remodeling; leaves open whether targeting dermatan sulfate affects bypass outcomes.
Marquezini et al. (2008) conducted an observational in Atherosclerosis in saphenous vein grafts. Atherosclerotic saphenous vein grafts vs. Normal saphenous veins was evaluated on Glycosaminoglycan composition. Atherosclerotic saphenous vein grafts had decreased total glycosaminoglycans and heparan sulfate, but increased relative amounts of dermatan and chondroitin sulfate compared with normal veins.
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