Key result
Histological examination of donor long saphenous veins prior to grafting revealed that all samples exhibited intimal fibrosis and muscle cell hypertrophy, deviating from normal appearances.
Why the study?
What are the baseline histological appearances of the long saphenous vein prior to its use as a bypass graft?
Observational
What are the baseline histological appearances of the long saphenous vein prior to its use as a bypass graft?
Pre-existing histological changes such as intimal fibrosis and muscle cell hypertrophy are present in long saphenous veins prior to grafting, suggesting that changes previously attributed to 'arterialization' may already exist and could contribute to graft failure.
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Pre-existing intimal changes may contribute to graft failure; leaves open whether remodeling precedes or follows arterialization.
Milroy et al. (1989) conducted an observational in Coronary artery and femoro-distal bypass surgery. Long saphenous vein prior to grafting vs. Described normal histological appearances was evaluated on Histological appearances (intimal fibrosis and muscle cell hypertrophy). Histological examination of donor long saphenous veins prior to grafting revealed that all samples exhibited intimal fibrosis and muscle cell hypertrophy, deviating from normal appearances.
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