Key result
Rosuvastatin significantly reduced the primary composite outcome of cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke by 50% (HR 0.50) in heart failure patients with low baseline YKL-40 levels.
Why the study?
Does rosuvastatin improve outcomes in patients with ischemic heart failure and low YKL-40 levels?
RCT (n=1,344)
Double-blind
Randomly assigned
Yes
Does rosuvastatin improve outcomes in patients with ischemic heart failure and low YKL-40 levels?
Hazard Ratio: 0.5 (95% CI 0.3–0.83)
p-value: p=0.006
Low serum YKL-40 levels may identify a specific subgroup of patients with ischemic heart failure who derive clinical benefit from statin therapy.
Supports rosuvastatin in low-YKL-40 ischemic HF; extends statin evidence to biomarker-selected subgroups.
CONTEXT AND OBJECTIVE: To evaluate if YKL-40 can provide prognostic information in patients with ischemic heart failure (HF) and identify patients who may benefit from statin therapy. MATERIALS AND METHODS: The association between serum YKL-40 and predefined outcome was evaluated in 1344 HF patients assigned to rosuvastatin or placebo. RESULTS: YKL-40 was not associated with outcome in adjusted analysis. In YKL-40 tertile 1, an effect on the primary outcome (HR 0.50, p = 0.006) and CV death (HR 0.54, p = 0.040) was seen by rosuvastatin in adjusted analysis. CONCLUSIONS: A beneficial modification of outcome was observed with statin therapy in patients with low YKL-40 levels.
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Arain et al. (2016) conducted an RCT in Chronic heart failure attributed to ischemic heart disease (n=1,344). Rosuvastatin vs. Placebo was evaluated on Composite of death from cardiovascular causes, non-fatal MI, and non-fatal stroke (HR 0.50, 95% CI 0.30-0.83, p=0.006). Rosuvastatin significantly reduced the primary composite outcome of cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke by 50% (HR 0.50) in heart failure patients with low baseline YKL-40 levels.
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