January 1, 2008Journal of Cardiovascular Magnetic ResonanceOpen Access

Uncomplicated obesity is associated with abnormal aortic function assessed by cardiovascular magnetic resonance

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Why the study?

Does uncomplicated obesity reduce aortic elastic function in adults without other cardiovascular risk factors?

Population

39 adults from Oxfordshire, UK, including 27 obese subjects without insulin resistance, normal cholesterol…

Comparison

Uncomplicated obesity (BMI ~33 kg/m2) vs Lean controls (BMI ~23 kg/m2)

Design

Cross-sectional

Authors

MRMonique RobinsonSaint Luke's Health System MSMichaela Scheuermann‐FreestoneUniversity of Nottingham PLPaul LeesonCardiac Imaging

Discussion

Member takes

Implication

May indicate early vascular changes in uncomplicated obesity; hypothesis-generating and requires longitudinal validation before clinical adoption.

Structured PICO

Does uncomplicated obesity reduce aortic elastic function in adults without other cardiovascular risk factors?

Population

39 adults from Oxfordshire, UK, including 27 obese subjects (BMI ~33 kg/m2) without insulin resistance, normal cholesterol, and normal blood pressure, and 12 lean controls (BMI ~23 kg/m2). Exclusions included hypertension, diabetes, insulin resistance, smoking, history of cerebrovascular or coronary artery disease, total cholesterol > 6 mmol/L, and abnormal renal, hepatic, or haematological function.

Intervention

Uncomplicated obesity (BMI ~33 kg/m2)

Comparator

Lean controls (BMI ~23 kg/m2)

Outcome

Aortic compliance, distensibility, and stiffness index measured by cardiovascular magnetic resonance (CMR)surrogate

Uncomplicated obesity is independently associated with abnormal aortic elastic function, highlighting its direct role in early cardiovascular disease pathogenesis independent of other traditional risk factors.

Limitations

Relatively small sample size
Lack of data on family history of cardiovascular disease
Lack of fat mass distribution assessment
Lack of other indices such as pulse wave velocity and central aortic pressure

Cite This Study

Robinson et al. (2008) studied this question.

synapsesocial.com/papers/6a89693207adfc24ebcb0142 https://doi.org/10.1186/1532-429x-10-10

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Implication

May indicate early vascular changes in uncomplicated obesity; hypothesis-generating and requires longitudinal validation before clinical adoption.

Uncomplicated obesity is associated with abnormal aortic function assessed by cardiovascular magnetic resonance

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Uncomplicated obesity is associated with abnormal aortic function assessed by cardiovascular magnetic resonance

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider