August 16, 2011Clinical and Experimental Pharmacology and Physiology
Adipokines and thrombosis
Key result
Specific adipokines, such as leptin, mediate the prothrombotic state in obesity by enhancing arterial and venous thrombosis, while vasculoprotective adiponectin levels are reduced.
Population
Obese individuals and mouse models of obesity
Design
Review
Authors
Discussion
Loading...
Member takes
Implication
Adipokine-targeted therapies may warrant investigation in obese patients with thrombosis risk; leaves open whether modulating leptin or adiponectin improves outcomes.
Structured PICO
P
Population
Obese individuals and mouse models of obesity
Adipokines such as leptin and adiponectin play a significant role in mediating the prothrombotic state associated with obesity, presenting potential therapeutic targets.
Cite This Study
Schäfer et al. (2011) conducted a review in Obesity and thrombosis. Obesity and adipokines was evaluated. Specific adipokines, such as leptin, mediate the prothrombotic state in obesity by enhancing arterial and venous thrombosis, while vasculoprotective adiponectin levels are reduced.