Key result
Liver transplantation in patients with familial amyloid polyneuropathy yielded a 1-year survival of 75.0% and 5-year survival of 64.2%, with cardiac complications as the leading cause of death.
Why the study?
What are the clinical outcomes and survival rates following liver transplantation or combined liver-heart transplantation in patients with familial amyloid polyneuropathy?
Population
20 patients with familial amyloid polyneuropathy who underwent liver transplantation between May 1998 and…
Design
Case_series
Follow-up
up to 5 years
Authors
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Modest post-transplant survival in FAP with cardiac deaths predominant; hypothesis-generating for combined heart-liver transplant in restrictive cardiomyopathy.
Cohort (n=20)
No
What are the clinical outcomes and survival rates following liver transplantation or combined liver-heart transplantation in patients with familial amyloid polyneuropathy?
In patients with familial amyloid polyneuropathy, clinical course post-liver transplantation is highly variable, and combined heart-liver transplantation should be considered for those with restrictive cardiomyopathy, particularly in non-Val30Met mutations.
Barreiros et al. (2010) conducted a cohort in Familial amyloid polyneuropathy (n=20). Liver transplantation was evaluated on 1-year and 5-year survival. Liver transplantation in patients with familial amyloid polyneuropathy yielded a 1-year survival of 75.0% and 5-year survival of 64.2%, with cardiac complications as the leading cause of death.
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