Key result
Orthotopic liver transplantation did not halt the development of cardiac conduction disturbances in FAP patients, with 4 of 30 patients requiring a pacemaker ≥40 months after transplantation.
Why the study?
Does orthotopic liver transplantation prevent the development of heart conduction and rhythm disturbances in patients with familial amyloidotic polyneuropathy?
Population
30 Swedish patients with familial amyloidotic polyneuropathy, Portuguese-Type who underwent orthotopic liver…
Comparison
Orthotopic liver transplantation (OLT) vs Pre-transplantation baseline
Design
Cohort
Authors
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May warrant ongoing Holter monitoring after liver transplant in FAP; leaves open optimal adjunctive strategies.
Cohort (n=30)
Does orthotopic liver transplantation prevent the development of heart conduction and rhythm disturbances in patients with familial amyloidotic polyneuropathy?
Liver transplantation does not halt the progression of cardiac conduction disturbances and arrhythmias in FAP patients, highlighting the need for continued Holter-ECG monitoring post-transplant.
Hörnsten et al. (2004) conducted a cohort in Familial amyloidotic polyneuropathy (FAP) (n=30). Orthotopic liver transplantation vs. Pre-transplantation baseline was evaluated on Heart conduction and rhythm disturbances on Holter-ECG. Orthotopic liver transplantation did not halt the development of cardiac conduction disturbances in FAP patients, with 4 of 30 patients requiring a pacemaker ≥40 months after transplantation.
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