Key result
Liver transplantation linked to increased left atrial diameter and septal thickness in ATTR Val30Met patients.
Why the study?
Does liver transplantation affect myocardial structure and function in patients with FAP ATTR Val30Met?
Population
12 Japanese patients with familial amyloid polyneuropathy amyloidgenic transthyretin Val30Met who underwent…
Comparison
Liver transplantation vs Preoperative baseline examinations
Design
Cohort
Follow-up
>2 years
Authors
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Cardiac amyloidosis may progress after liver transplantation in FAP ATTR Val30Met; leaves open need for ongoing surveillance and adjunctive therapies.
Cohort (n=12)
No
Does liver transplantation affect myocardial structure and function in patients with FAP ATTR Val30Met?
p-value: p=<0.05
In patients with FAP ATTR Val30Met, cardiac amyloidosis continues to progress after liver transplantation, as evidenced by increased left atrial diameter and septal thickness.
Okamoto et al. (2008) conducted a cohort in Familial amyloid polyneuropathy (FAP) ATTR Val30Met (n=12). Liver transplantation vs. Preoperative baseline was evaluated on Changes in left atrial diameter (LAD) and interventricular septal thickness (IVS) (p=<0.05). Left atrial diameter and interventricular septal thickness significantly increased after liver transplantation compared to preoperative baseline in Japanese patients with familial amyloid polyneuropathy ATTR Val30Met.
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