Why the study?
Does liver transplantation improve cardiac sympathetic denervation and amyloid infiltration in patients with familial amyloid polyneuropathy?
Population
31 patients with Familial amyloid polyneuropathy (FAP), mean age 39 +/- 12 years.
Comparison
Liver transplantation (LT) vs Pre-transplantation baseline and 12 control…
Design
Cohort
Follow-up
24 +/- 15 months
Authors
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Cardiac amyloid may progress after LT in FAP despite stable denervation; leaves open whether earlier intervention or adjunctive therapies alter outcomes.
Does liver transplantation improve cardiac sympathetic denervation and amyloid infiltration in patients with familial amyloid polyneuropathy?
Liver transplantation in familial amyloid polyneuropathy does not reverse cardiac sympathetic denervation and does not halt the progression of cardiac amyloid infiltration.
Delahaye et al. (2006) studied this question.
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