Key result
Liver transplantation fails to prevent arrhythmias requiring pacemaker insertion in familial amyloidotic polyneuropathy.
Why the study?
Only a few studies have analyzed the development of arrhythmia in transplant patients with familial amyloidotic polyneuropathy (FAP).
Does liver transplantation prevent the development of arrhythmia requiring pacemaker insertion in patients with familial amyloidotic polyneuropathy?
Design
Cohort study
Follow-up
Median of 11 years after disease onset
Authors
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Ongoing arrhythmia surveillance is warranted after liver transplantation in familial amyloidotic polyneuropathy; this cohort study leaves open whether transplant modifies cardiac progression.
Cohort (n=104)
Does liver transplantation prevent the development of arrhythmia requiring pacemaker insertion in patients with familial amyloidotic polyneuropathy?
Liver transplantation does not prevent the continuous development of heart arrhythmia necessitating pacemaker insertion in patients with familial amyloidotic polyneuropathy.
Okamoto et al. (2010) conducted a cohort in Familial amyloidotic polyneuropathy (FAP) (n=104). Liver transplantation was evaluated on Development of arrhythmia requiring pacemaker insertion (PMI). Liver transplantation did not prevent heart arrhythmia requiring pacemaker insertion, which occurred in 25% (26 of 104) of patients with familial amyloidotic polyneuropathy over a median of 11 years.
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