Malignant Insulinoma: Effects of a Somatostatin Analog (Compound 201-995) on Serum Glucose, Growth, and Gastro-Entero-Pancreatic Hormones

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Brief Reports1 August 1985Malignant Insulinoma: Effects of a Somatostatin Analog (Compound 201-995) on Serum Glucose, Growth, and Gastro-Entero-Pancreatic HormonesKWAME OSEI, M. D., THOMAS M. O'DORISIO, M.D.KWAME OSEI, M. D.Search for more papers by this author, THOMAS M. O'DORISIO, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-103-2-223 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptVarious therapies have been used to treat patients with active malignant insulinoma (1-3), which comprises 10% of all beta-cell tumors of the pancreas (1). Somatostatin, a tetradecapeptide found in the hypothalamus and gastro-entero-pancreatic system, suppresses several endocrine hormones (4). However, because of the short halflife (5 to 10 minutes) of endogenous somatostatin, several analogs with longer-acting properties have been synthesized (5). Recently, compound 201-995 (Sandoz Pharmaceutical, Inc., East Hanover, New Jersey), an octapeptide with a 10 to 20 times longer half-life and a 50 to 100 times greater potency has become available in United States. We report the use of...References1. BRODER L and CARTER S. Pancreatic islet cell carcinoma: II. Results of therapy with streptozotocin in 52 patients. Ann Intern Med. 1973;19:108-18. LinkGoogle Scholar2. GRABER A, PORTE D, and WILLIAMS R. Clinical use of diazoxide and mechanism for its hyperglycemic effects. Diabetes. 1966;15:143-8. CrossrefMedlineGoogle Scholar3. OSEI K, FALKO J, NELSON K, and STEPHENS R. Diabetogenic effect of Pentamidine: in vitro and in vivo studies in a patient with malignant insulinoma. Am J Med. 1984;77:41-6. CrossrefMedlineGoogle Scholar4. ADRIAN T, BARNES A, and LONG R. The effect of somatostatin analogs on secretion of growth, pancreatic and gastrointestinal hormones. J Clin Endocrinol Metab. 1981;53:675-81. CrossrefMedlineGoogle Scholar5. SHEPPARD M, SHAPIRO B, PINSTONE B, KRONHEIM S, BERELOVITZ M, and GREGORY M. Metabolic clearance and plasma half-disappearance time of exogenous somatostatin in man. J Clin Endocrinol Metab. 1979;48:50-3. CrossrefMedlineGoogle Scholar6. SHERMAN B, PEK S, FAJANS S, FLOYD J, and CONN J. Plasma proinsulin in patients with functioning pancreatic islet cell tumor. J Clin Endocrinol Metab. 1972;35:271-80. CrossrefMedlineGoogle Scholar7. BAR R, GORDEN P, ROTH J, and SIEBERT C. Insulin receptors in patients with insulinoma: changes in receptor affinity and concentration. J Clin Endocrinol Metab. 1977;44:1210-3. CrossrefMedlineGoogle Scholar8. KRAENZLIN M, CH'NG J, WOOD S, and BLOOM S. Can inhibition of hormone secretion be associated with endocrine tumor shrinkage [Letter]? Lancet. 1983;2:1501. CrossrefMedlineGoogle Scholar9. JONES C, MILLER J, LAWRIE C, SUMMER D, and REID J. Specific inhibition of aldosterone responses to endogenous and exogenous angiotensin II by somatostatin. Clin Endocrinol. 1984;21:279-84. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: KWAME OSEI, M. D.; THOMAS M. O'DORISIO, M.D.Affiliations: The Ohio State University College of Medicine Columbus, Ohio. 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