Why the study?
Does intracoronary infusion of substance P relieve spontaneous coronary artery spasm in a patient with anginal chest pain?
Does intracoronary infusion of substance P relieve spontaneous coronary artery spasm in a patient with anginal chest pain?
Intracoronary infusion of the endothelium-dependent vasodilator substance P immediately relieved spontaneous coronary artery spasm, suggesting that endothelium-dependent vasodilation is preserved at spastic sites.
Supports preserved endothelial vasodilator response in spasm; hypothesis-generating from one case and should not change practice.
This report describes a 45-year-old Japanese man who had episodes of anginal chest pain on effort. Coronary arteriography in the baseline state revealed subtotal occlusion in the mid-portion of the left anterior descending coronary artery. After intracoronary infusion of an endothelium-dependent vasodilator, substance P, the subtotal occlusion was immediately abolished. We concluded that endothelium-dependent vasodilation evoked with substance P was present at the site where coronary vasospasm occurred spontaneously in our case.
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Numaguchi et al. (1995) studied this question.
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