Key result
Patients with severe coronary artery stenosis exhibited significant deviations from theoretical optimal retinal arteriolar bifurcation angles, including a decrease in θ'1 and an increase in θ'2, compared to those with moderate stenosis.
Why the study?
The study was designed to examine the relationship between the morphological parameters of retinal arteriolar bifurcations and coronary artery disease.
Does retinal arteriolar bifurcation morphology correlate with the severity of coronary atherosclerosis in patients undergoing coronary imaging?
Population
444 participants
Comparison
Different levels of coronary atherosclerosis severity
Design
Cross-sectional observational study
Authors
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Retinal angle deviations may signal severe stenosis; hypothesis-generating for noninvasive CAD markers, requiring prospective validation before any practice change.
Cross-Sectional (n=444)
Single-blind
No
Does retinal arteriolar bifurcation morphology correlate with the severity of coronary atherosclerosis in patients undergoing coronary imaging?
Absolute Event Rate: 36.239% vs 36.466%
p-value: p=0.003
Retinal arteriolar bifurcation morphology shows significant deviations in patients with severe coronary artery disease, suggesting its potential as a non-invasive indicator of CAD severity.
Dai et al. (2024) conducted a cross-sectional in Coronary artery disease (n=444). Severe coronary artery stenosis vs. Mild to moderate coronary artery stenosis was evaluated on Theoretical optimal bifurcation angle (θ'1) (p=0.003). Patients with severe coronary artery stenosis exhibited significant deviations from theoretical optimal retinal arteriolar bifurcation angles, including a decrease in θ'1 and an increase in θ'2, compared to those with moderate stenosis.
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