Key result
Early valve surgery was not associated with reduced 1-year mortality in patients with Staphylococcus aureus prosthetic valve infective endocarditis (adjusted RR 0.67; 95% CI 0.39-1.15; P=0.15).
Why the study?
Does early valve surgery reduce 1-year all-cause mortality in patients with Staphylococcus aureus prosthetic valve infective endocarditis?
Cohort (n=168)
Yes
Does early valve surgery reduce 1-year all-cause mortality in patients with Staphylococcus aureus prosthetic valve infective endocarditis?
Relative Risk: 0.67 (95% CI 0.39–1.15)
Absolute Event Rate: 33.8% vs 59.1%
p-value: p=0.15
Early valve surgery within 60 days of hospitalization was not associated with a significant reduction in 1-year mortality among patients with Staphylococcus aureus prosthetic valve infective endocarditis.
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Does not support early surgery to reduce mortality in S aureus prosthetic valve IE; leaves open need for randomized trials.
Chirouze et al. (2014) conducted a cohort in Staphylococcus aureus prosthetic valve infective endocarditis (n=168). Early valve surgery (within 60 days of hospitalization) vs. No early valve surgery was evaluated on 1-year all-cause mortality (RR 0.67, 95% CI 0.39-1.15, p=0.15). Early valve surgery was not associated with reduced 1-year mortality in patients with Staphylococcus aureus prosthetic valve infective endocarditis (adjusted RR 0.67; 95% CI 0.39-1.15; P=0.15).
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